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藤黃果與白腎豆萃取物對於台灣肥胖成人之臨床評估 Back
盧志輝(Chih-Huei Lu) ； 楊宗翰(Tsung-Han Yang) ； 吳志忠(Chih-Chung Wu) ； 董家堯(Jia-Yau Doong) ； 林佩瑩(Pei-Ying Lin) ； 江啟銘(Chi-Ming Chiang) ； 林建良(Chien-Liang Lin) ； 謝淑玲(Shu-Ling Hsieh)
臺灣營養學會雜誌 ； 37卷2期 (2012 / 06 / 01) ， P75 - 84
過重與肥胖是許多國家嚴重的公衛問題。本研究使用藤黃果萃取物（Garcinia cambogia extract）與白腎豆萃取物（Phaseolus vulgaris extract）對台灣地區的過重成年人進行八週的臨床評估。本研究共募集到114位過重成年人，以隨機分組之方式將所有受試者分為三組：藤黃果萃取物組（使用Super CitriMax）、白腎豆萃取物組（使用Phase 2）與安慰劑組（使用Maltodextrin），每天分別介入2800mg的藤黃果萃取物、白腎豆萃取物或安慰劑，持續八週，介入期間不限制受試者的飲食，並於第0週起每兩週對受試者進行一次營養教育與身體測量，而血液生化檢驗分別於第0週與第8週時進行。實驗結果顯示，體位測量在第8週與第0週時相比，安慰劑組受試者於腰圍、臀圍、大腿圍都有顯著增加，藤黃果萃取物組受試者有維持腰圍、臀圍、腰臀比的效果，白腎豆萃取物組受試者則亦在臀圍、腰臀比有維持的效果。在血液生化分析的結果可發現藤黃果萃取物組受試者8週後具有降低AST與穩定空腹血糖的效果，白腎豆萃取物組8週後具有提高HDL的效果。
Weight reduction and maintenance with IQP-PV-101: a 12-week randomized controlled study with a 24-week open label period
Abstract
Objective: The safety and efficacy of IQP-PV-101, a proprietary extract of Phaseolus vulgaris, on weight management in two phases was evaluated here. The weight loss (WL) phase was conducted over 12 weeks and the weight maintenance (WM) phase took 24 weeks.
Methods: In the double-blind WL phase, subjects were randomized to receive either IQP-PV-101 or placebo. All subjects adhered to a mildly hypocaloric diet. Body weight and other body composition parameters were measured at baseline and every 4 weeks thereafter. During the single arm, open label WM trial, energy intake was ad libitum. Efficacy parameters were measured at baseline, week 12 and week 24.
Results: At the end of the WL study, the IQP-PV-101 group lost a mean of 2.91 ± 2.63 kg in body weight compared with 0.92 ± 2.00 kg in the placebo group (P < 0.001). During the WM phase, 36 out of 49 subjects (73.5%) were able to maintain their weight, even without dietary restrictions. No serious or related adverse events were reported over the combined period of 36 weeks.
Conclusions: Results indicate that IQP-PV-101 is safe and effective for weight loss and maintenance.
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